Prolonged endotracheal intubation is associated with quite a few complications including ventilator associated pneumonia, airway damage, or threat of reintubation. Reintubation is a particular drawback particularly because of the lack to cooperate with peri-extubation maneuvers, and the relatively excessive sedation requirements. Children who have extreme thirst may have excessive blood sugar ranges. In conclusion, a number of research have urged that prophylactic NIV could reduce the risk of submit-extubation respiratory failure in ICU patients at high danger of extubation failure. Further research are wanted to elucidate the efficacy of HFNC throughout weaning from prolonged mechanical ventilation in a bigger inhabitants to forestall publish-extubation respiratory failure in patients at high threat of extubation failure within the intensive care unit and such a clinical condition the place NIV is just not recommended. 106 mm Hg), in an effort to keep away from tracheostomy on ICU day sixteen the primary weaning try was made. We suggest that the first setting of HFNC stream be the identical as the utmost inspiratory circulate of the ventilator throughout pressure assist ventilation, and the duration of HFNC be step by step extended together with physiotherapy rehabilitation. It will be significant, nonetheless, that you simply focus on this with your private physician and first receive acceptable lab checks